Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AAUUGAGCUGGAGAGGAGGCAGCGUGAGAGCAGAAACUUCAGACGCCGC… | 7328 nt | 0.4730 | |
| GCAUUAAUAGUAAUACAGAUAACGGGUUUGAAAGAAUUCUCUACUGAAG… | 6927 nt | 0.4461 | |
| AAUUGAGCUGGAGAGGAGGCAGCGUGAGAGCAGAAACUUCAGACGCCGC… | 7493 nt | 0.4708 |
Summary
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Forensic Context
A study in humans demonstrated that the ROBO1 mRNA transcript exhibited a 4-fold higher expression in CEU (European) populations compared to Asians in lymphoblastoid cell line studies, indicating its potential for population differentiation [Daca-Roszak & Zietkiewicz DOI:10.1007/s13353-019-00510-1]. In a separate investigation of peripheral blood from Chinese individuals, the ROBO1 was identified as a differentially expressed gene showing a steady decline in expression with advancing age and was linked to inflammaging, contributing to a robust age prediction model [Liao et al. DOI:10.1016/J.Fsigen.2025.103373].