Basic Information

Symbol
ROBO4
RNA class
mRNA
Alias
Roundabout Guidance Receptor 4 ECSM4 MRB Roundabout Homolog 4 Magic Roundabout FLJ20798 Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) Roundabout, Axon Guidance Receptor, Homolog 4 Roundabout Homolog 4, Magic Roundabout Roundabout Homolog 4 (Drosophila) AOVD3
Location (GRCh38)
11:124883666-124898500
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mixture deconvolution Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_019055.6
Sequence length
4294.0 nt
GC content
0.5964

Transcripts

ID Sequence Length GC content
NM_001301088.2 NCBI
CCCUCUUCACUGUGAGCUCAGAGCAGCAGGACAAAGUGCUCGGGACAAG… 4088 nt 0.5930
NM_019055.6 NCBI
CCCUCUUCACUGUGAGCUCAGAGCAGCAGGACAAAGUGCUCGGGACAAG… 4294 nt 0.5964
Summary

Predicted to enable cell-cell adhesion mediator activity. Involved in establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3. Biomarker of pre-eclampsia and thyroid gland carcinoma. [provided by Alliance of Genome Resources, Jul 2025] CIViC Summary for ROBO4 Gene

Forensic Context

A review of multi-omics studies for human biological age estimation identified the ROBO4 as a proteomic aging biomarker with higher abundance in the age-dependent urine proteome of healthy men [Solovev et al. DOI:10.1016/j.mad.2019.111192]. A study in humans demonstrated that the ROBO4 exhibited a Gini impurity score of 0, being present in most pure urine samples and in some mixtures containing urine while being absent in mixtures without urine, supporting its role as a discriminatory protein for body fluid classification [Shehata et al. DOI:10.1016/j.fsigen.2025.103343].