Basic Information

Symbol
ROR1
RNA class
mRNA
Alias
Receptor Tyrosine Kinase Like Orphan Receptor 1 NTRKR1 Inactive Tyrosine-Protein Kinase Transmembrane Receptor ROR1 Neurotrophic Tyrosine Kinase, Receptor-Related 1 EC 2.7.10.1 DJ537F10.1
Location (GRCh38)
1:63774017-64181498
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005012.4
Sequence length
5858.0 nt
GC content
0.4418

Transcripts

ID Sequence Length GC content
NM_001083592.2 NCBI
AAGUUGAGCGAGAGAGGGAGCGUGGAGAGCUGGAGCAGCCGCCACCGCC… 2310 nt 0.5242
NM_005012.4 NCBI
AAGUUGAGCGAGAGAGGGAGCGUGGAGAGCUGGAGCAGCCGCCACCGCC… 5858 nt 0.4418
Summary

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Forensic Context

A study in zebrafish demonstrated that the ROR1 transcript, categorized as a cancer-associated gene, increased in abundance postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267].