Basic Information

Symbol
RORC
RNA class
mRNA
Alias
RAR Related Orphan Receptor C NR1F3 RZRG RORG Nuclear Receptor ROR-Gamma TOR Nuclear Receptor Subfamily 1 Group F Member 3 RAR-Related Orphan Receptor C Nuclear Receptor RZR-Gamma Retinoid-Related Orphan Receptor Gamma Retinoid-Related Orphan Receptor-Gamma Retinoic Acid-Binding Receptor Gamma RZR-GAMMA IMD42
Location (GRCh38)
1:151806071-151831845
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005060.4
Sequence length
2996.0 nt
GC content
0.5594

Transcripts

ID Sequence Length GC content
NM_001001523.2 NCBI
AGUCCAGAAGCACUGGGGGAGAGAGCUAGGUGCAGAGCUUCAGGCUGAG… 3055 nt 0.5610
NM_005060.4 NCBI
AGCCAGGGCAGCCAGGACGGCACCAAGGGAGCUGCCCCAUGGACAGGGC… 2996 nt 0.5594
Summary

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rats demonstrated that long-term methamphetamine consumption induced heart failure, characterized by decreased ejection fraction and myocardial contractility, and identified the RORC as a candidate biomarker and an important hub gene in the protein-protein interaction network, with its differential mRNA expression confirmed by qRT-PCR in left ventricular tissue [Zhang et al. DOI:10.1016/J.Taap.2022.116172].