Basic Information

Symbol
RPL15
RNA class
mRNA
Alias
Ribosomal Protein L15 EC45 RPLY10 RPYL10 RPL10 EL15 L15 Large Ribosomal Subunit Protein EL15 60S Ribosomal Protein L15 DBA12
Location (GRCh38)
3:23916591-23924374
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002948.5
Sequence length
2155.0 nt
GC content
0.4172

Transcripts

ID Sequence Length GC content
NM_001253379.2 NCBI
UGGAGGAGCUUCACGCAGUCUGGAGCUGAAGGGACACAGCGAGCGCCCC… 2743 nt 0.4728
NM_001253380.2 NCBI
GGCUGAGGUGGGGGAGGAGCCCAAAAGGCAUUGUGGGAGUACAGCUCUU… 2853 nt 0.4616
NM_001253382.2 NCBI
GGCUGAGGUGGGGGAGGAGCCCAAAAGGCAUUGUGGGAGUACAGCUCUU… 2299 nt 0.4298
NM_001253383.3 NCBI
GGGAGUACAGCUCUUUCCUUUCCGUCUGGCGGCAGCCAUCAGGUAGGCU… 2221 nt 0.4205
NM_001253384.2 NCBI
UGGAGGAGCUUCACGCAGUCUGGAGCUGAAGGGACACAGCGAGCGCCCC… 4033 nt 0.4927
NM_002948.5 NCBI
GGGAGUACAGCUCUUUCCUUUCCGUCUGGCGGCAGCCAUCAGGUAAGCC… 2155 nt 0.4172
Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

Forensic Context

A study in humans identified numerous mRNA markers in blood for age estimation, with the RPL15 previously found to be associated with age in blood [Dørum et al. DOI:10.1016/j.fsigen.2023.102976].