Basic Information

Symbol
RPL3
RNA class
mRNA
Alias
Ribosomal Protein L3 UL3 L3 Large Ribosomal Subunit Protein UL3 HIV-1 TAR RNA-Binding Protein B 60S Ribosomal Protein L3 TARBP-B ASC-1
Location (GRCh38)
22:39312870-39320389
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000967.4
Sequence length
1296.0 nt
GC content
0.5432

Transcripts

ID Sequence Length GC content
NM_000967.4 NCBI
CUCUACCGGCGGGAUUUGAUGGCGUGAUGUCUCACAGAAAGUUCUCCGC… 1296 nt 0.5432
NM_001033853.2 NCBI
CUCUACCGGCGGGAUUUGAUGGCGUGAUGUCUCACAGAAAGUUCUCCGC… 1149 nt 0.5448
Summary

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the RPL3 was identified by homology as a hypoxia/asphyxia marker candidate but showed an asphyxia-independent expression pattern in comparative RT-PCR validation, with no significant differential expression observed between groups subjected to neck ligation-induced hypoxia and control groups [Ikematsu et al. DOI:10.1016/J.Forsciint.2006.08.015].