Basic Information

Symbol
RPL38
RNA class
mRNA
Alias
Ribosomal Protein L38 EL38 L38 Large Ribosomal Subunit Protein EL38 60S Ribosomal Protein L38
Location (GRCh38)
17:74202841-74210655
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000999.4
Sequence length
1145.0 nt
GC content
0.5013

Transcripts

ID Sequence Length GC content
NM_000999.4 NCBI
CUUUUUCGUCCUUUUCCCCGGUUGCUGCUUGCUGUGAGUGUCUCUAGGG… 1145 nt 0.5013
NM_001035258.2 NCBI
CUUUUUCGUCCUUUUCCCCGGUUGCUGCUUGCUGUCCUGGUCCGCGCCA… 1110 nt 0.5009
Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans using a custom-designed mRNA MPS primer panel for time since deposition (TsD) estimation in four body fluids (blood, semen, menstrual blood, and vaginal secretion) found that the RPL38 was included as a candidate mRNA marker [Hänggi et al. DOI:10.1016/j.fsigen.2025.103415]. A study in humans demonstrated that the RPL38 was identified as a highly expressed housekeeping gene exhibiting a low coefficient of variation across individuals differing in genetics, environment, age, and gender [Sharma et al. DOI:10.1152/physiolgenomics.00228.2003].