Basic Information

Symbol
RPN2
RNA class
mRNA
Alias
Ribophorin II RIBIIR RPN-II RPNII SWP1 Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 63 KDa Subunit Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 2 Oligosaccharyltransferase Complex Subunit (Non-Catalytic) Ribophorin-2 EC 2.4.1.119
Location (GRCh38)
20:37178396-37241624
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002951.5
Sequence length
2227.0 nt
GC content
0.4908

Transcripts

ID Sequence Length GC content
NM_001135771.3 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2179 nt 0.4888
NM_001324299.2 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2179 nt 0.4855
NM_001324301.2 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2323 nt 0.4916
NM_001324302.2 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2131 nt 0.4857
NM_001324303.2 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2222 nt 0.4910
NM_001324304.2 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2275 nt 0.4905
NM_001324305.2 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2275 nt 0.4919
NM_001324306.2 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2003 nt 0.4868
NM_002951.5 NCBI
GGACUCCGGCGGGACCUGCUCGGAGGAAUGGCGCCGCCGGGUUCAAGCA… 2227 nt 0.4908
Summary

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the RPN2 in oligodendrocytes, specifically within the protein processing of endoplasmic reticulum pathway [Oladapo et al. DOI:10.3390/Ijms26020649].