Basic Information

Symbol
RPS29
RNA class
mRNA
Alias
Ribosomal Protein S29 US14 S29 Small Ribosomal Subunit Protein US14 40S Ribosomal Protein S29 DBA13
Location (GRCh38)
14:49570984-49599164
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001032.5
Sequence length
295.0 nt
GC content
0.4610

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-80.8 kcal/mol
Thermodynamic ensemble
Free energy: -87.62 kcal/mol
Frequency: 0.0000
Diversity: 44.56
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..............((((((((((((.((.(......).))..)))))).)))((.(((((.((((((.........))..))))....))))).))((((((.((....)).))))))((((((..((((((((((((..((.....))..)))).)))))))))))).))(((((((((((((((((((((.(((.(((.....((((((((((....))))......)))))))))))).)))))..))))..))).)))))))))..........))).............
Thermodynamic Ensemble Prediction
.....,{{{....,{,{(((((((((.((.(......).))..)))))).)))}|.{((((.{(((((((....}},,}..))))....))))}.},((((((.((....)).))))))((((((..((((((((((((..((.....})..)))}.)))))))))))).))(((((((((((((((((((((.(({,(((.....((((((((((....))))......)))))))))))).))))),.,)))..))),,))))))))................,}},,.....

Transcripts

ID Sequence Length GC content
NM_001030001.4 NCBI
CUUCCUUUUACCUCGUUGCACUGCUGAGAGCAAGAUGGGUCACCAGCAG… 7062 nt 0.4283
NM_001032.5 NCBI
CUUCCUUUUACCUCGUUGCACUGCUGAGAGCAAGAUGGGUCACCAGCAG… 295 nt 0.4610
NM_001351375.2 NCBI
UGGCAGCGGUGGUUGUUUCUGUUCGGGGAGGAUUCCGAGGGUUUCAGCU… 510 nt 0.5196
Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Forensic Context

A study in rats and humans demonstrated that the RPS29 proved to be stable and was selected as a reference biomarker for both lung and muscle tissues in postmortem interval estimation models [Lv et al. DOI:10.1016/j.jflm.2016.08.015]. Research on human brain tissues further found the RPS29 to be a stable reference gene in aged formalin-fixed paraffin-embedded samples [Lv et al. DOI:10.1007/s00414-019-02210-1]. A study in mice demonstrated that the RPS29 was investigated as a potential reference gene for post-mortem interval (PMI) estimation [Scrivano et al. DOI:10.1007/s00414-019-02125-x], and a subsequent systematic review confirmed its study for stability and use as a reference control gene in such models [Cianci et al. DOI:10.3390/ijms25158185].