Basic Information

Symbol
RPS6KB1
RNA class
mRNA
Alias
Ribosomal Protein S6 Kinase B1 S6K1 P70(S6K)-Alpha STK14A PS6K S6K Serine/Threonine-Protein Kinase 14A Ribosomal Protein S6 Kinase Beta-1 Ribosomal Protein S6 Kinase I EC 2.7.11.1 S6K-Beta-1 P70 S6KA Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 Ribosomal Protein S6 Kinase, 70kD, Polypeptide 1 70 KDa Ribosomal Protein S6 Kinase 1 Serine/Threonine Kinase 14 Alpha P70 Ribosomal S6 Kinase Alpha P70 S6 Kinase Alpha P70 S6K-Alpha P70-Alpha P70-S6K 1 EC 2.7.11 P70-S6K P70S6K1
Location (GRCh38)
17:59893046-59950574
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003161.4
Sequence length
5428.0 nt
GC content
0.3716

Transcripts

ID Sequence Length GC content
NM_001272042.2 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5359 nt 0.3719
NM_001272043.2 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 4238 nt 0.3740
NM_001272044.2 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5557 nt 0.3754
NM_001272060.2 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5428 nt 0.3716
NM_001369669.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5320 nt 0.3699
NM_001369670.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5364 nt 0.3695
NM_001369671.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5188 nt 0.3699
NM_001369672.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5449 nt 0.3738
NM_001369673.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5632 nt 0.3764
NM_001369674.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5681 nt 0.3767
Showing 1 to 10 of 16 entries
Summary

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the RPS6KB1 in microglia, as part of a broad disruption of autophagy pathways revealed by single-cell RNA sequencing [Oladapo et al. DOI:10.3390/Ijms26020649].