Basic Information

Symbol
RPS6KB1
RNA class
mRNA
Alias
Ribosomal Protein S6 Kinase B1 S6K1 P70(S6K)-Alpha STK14A PS6K S6K Serine/Threonine-Protein Kinase 14A Ribosomal Protein S6 Kinase Beta-1 Ribosomal Protein S6 Kinase I EC 2.7.11.1 S6K-Beta-1 P70 S6KA Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 Ribosomal Protein S6 Kinase, 70kD, Polypeptide 1 70 KDa Ribosomal Protein S6 Kinase 1 Serine/Threonine Kinase 14 Alpha P70 Ribosomal S6 Kinase Alpha P70 S6 Kinase Alpha P70 S6K-Alpha P70-Alpha P70-S6K 1 EC 2.7.11 P70-S6K P70S6K1
Location (GRCh38)
17:59893046-59950574
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003161.4
Sequence length
5428.0 nt
GC content
0.3716

Transcripts

ID Sequence Length GC content
NM_001369675.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5573 nt 0.3752
NM_001369676.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5406 nt 0.3716
NM_001369677.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5756 nt 0.3777
NM_001369678.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5503 nt 0.3727
NM_001369679.1 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5760 nt 0.3778
NM_003161.4 NCBI
GCACUGAGCCUAAGCAGCCGGUGAUGGCGGCAGCGGCUGUGGUGGCUGC… 5428 nt 0.3716
Showing 11 to 16 of 16 entries
Summary

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the RPS6KB1 in microglia, as part of a broad disruption of autophagy pathways revealed by single-cell RNA sequencing [Oladapo et al. DOI:10.3390/Ijms26020649].