Basic Information

Symbol
RRAD
RNA class
mRNA
Alias
RRAD, Ras Related Glycolysis Inhibitor And Calcium Channel Regulator RAD REM3 RRAD, Ras Related Glycolysis Inihibitor And Calcium Channel Regulator Ras-Related Associated With Diabetes Ras Associated With Diabetes GTP-Binding Protein RAD RAD1 RAS (RAD And GEM) Like GTP Binding 3
Location (GRCh38)
16:66921682-66926308
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004165.3
Sequence length
1460.0 nt
GC content
0.6514

Transcripts

ID Sequence Length GC content
NM_001128850.2 NCBI
AGUGCGGGCUGAGAAGGCGGUGGCUGCAGCAGCAGCGGCGGCGGAAACC… 1469 nt 0.6508
NM_004165.3 NCBI
AGUGCGGGCUGAGAAGGCGGUGGCUGCAGCAGCAGCGGCGGCGGAAACC… 1460 nt 0.6514
Summary

Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in T-tubule. Predicted to be active in plasma membrane. Implicated in type 2 diabetes mellitus. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans and mice demonstrated that the RRAD is a GTPase regulating L-type Ca2+ channels and serves as a marker for molecular niche 2, which is enriched in damaged tissue areas in border zones after myocardial infarction [Kuppe et al. DOI:10.1038/s41586-022-05060-x]. It was identified as a target gene of ATF3 within the cardiomyocyte enhancer gene-regulatory network associated with the stressed vCM3 state. A study in mice demonstrated that the RRAD mRNA was down-regulated (0.31-fold) in bone marrow cells 6 hours after a 6.5 Gy whole-body ionizing radiation exposure [Dai et al. DOI:10.1080/09553000600857389].