Basic Information

Symbol
RRAGC
RNA class
mRNA
Alias
Ras Related GTP Binding C GTR2 Ras-Related GTP-Binding Protein C GTPase-Interacting Protein 2 FLJ13311 TIB929 Ras-Related GTP Binding C Rag C Protein EC 3.6.5.- LNGODS LNGOS Rag C RAGC RagC
Location (GRCh38)
1:38838198-38859772
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022157.4
Sequence length
2681.0 nt
GC content
0.4427

Transcripts

ID Sequence Length GC content
NM_001271851.2 NCBI
GGACUGUGGCGGCUGCCGGGGGCGGUGGCGGUGGUGGCGGCGGCGGCGG… 2579 nt 0.4447
NM_022157.4 NCBI
GGACUGUGGCGGCUGCCGGGGGCGGUGGCGGUGGUGGCGGCGGCGGCGG… 2681 nt 0.4427
Summary

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the RRAGC in microglia, where it is involved in the autophagy pathway [Oladapo et al. DOI:10.3390/Ijms26020649].