Basic Information

Symbol
RRAS2
RNA class
mRNA
Alias
RAS Related 2 TC21 Related RAS Viral (R-Ras) Oncogene Homolog 2 Ras-Related Protein R-Ras2 Teratocarcinoma Oncogene Ras-Like Protein TC21 EC 3.6.5.2 NS12
Location (GRCh38)
11:14277922-14364506
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012250.6
Sequence length
2343.0 nt
GC content
0.4277

Transcripts

ID Sequence Length GC content
NM_001102669.2 NCBI
GGGAGGGCGGAGCUGGAAGGGUGGGAAGCACCGAUCCACCUUAUUGCUC… 2209 nt 0.3952
NM_001177314.2 NCBI
AUCUCAGAUGCAUGCAGCUCCUGCUGGGCGGUUUCAUUCUCUGCCAGCC… 2038 nt 0.3587
NM_001177315.1 NCBI
AUUGCUCUGGCCGAGGCCAGAGACCUCCGGGAGAGGCUGGGCCACCGAG… 2186 nt 0.3893
NM_012250.6 NCBI
AGACGGCCAUUUGUGGCGGCGCUGGAGGCUGCGUUCGGCAGGCGCUGCG… 2343 nt 0.4277
Summary

This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] CIViC Summary for RRAS2 Gene

Forensic Context

A study in mice demonstrated that the RRAS2 is a direct transcriptional target of the lncRNA Gm18840, with its promoter/enhancer activity being directly regulated by Gm18840 during myocardial ischemia-reperfusion injury [Luo et al. DOI:10.3389/fcell.2021.615950].