Basic Information

Symbol
RRM2
RNA class
mRNA
Alias
Ribonucleotide Reductase Regulatory Subunit M2 Ribonucleoside-Diphosphate Reductase Subunit M2 Ribonucleotide Reductase M2 Polypeptide Ribonucleotide Reductase Small Subunit Ribonucleotide Reductase Small Chain EC 1.17.4.1 FLJ25102 C2orf48 RR2 Chromosome 2 Open Reading Frame 48 Uncharacterized Protein C2orf48 RR2M R2
Location (GRCh38)
2:10120698-10211725
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001034.4
Sequence length
3258.0 nt
GC content
0.4208

Transcripts

ID Sequence Length GC content
NM_001034.4 NCBI
GUGCACCCUGUCCCAGCCGUCCUGUCCUGGCUGCUCGCUCUGCUUCGCU… 3258 nt 0.4208
NM_001165931.1 NCBI
AAAAUCGCGCGCGGCCCCGCGGCCAGCCUGGGUAGGGGCAAGGCGCAGC… 3452 nt 0.4322
Summary

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] CIViC Summary for RRM2 Gene

Forensic Context

A study in mice demonstrated that the RRM2 transcript, a marker for DNA replication, was upregulated 3.5-fold in the injured ipsilateral neocortex three days post-injury in a closed head weight-drop model of mild traumatic brain injury [Israelsson et al. DOI:10.1089/neu.2008.0676].