Basic Information

Symbol
RSAD2
RNA class
mRNA
Alias
Radical S-Adenosyl Methionine Domain Containing 2 Viperin Cig5 Vig1 Virus Inhibitory Protein, Endoplasmic Reticulum-Associated, Interferon-Inducible S-Adenosylmethionine-Dependent Nucleotide Dehydratase RSAD2 Radical S-Adenosyl Methionine Domain-Containing Protein 2 Cytomegalovirus-Induced Gene 5 Protein SAND Virus-Inhibitory Protein, Endoplasmic Reticulum–Associated, Interferon-Inducible EC 4.2.-.- Cig33 CIG5
Location (GRCh38)
2:6865557-6898239
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_080657.5
Sequence length
3407.0 nt
GC content
0.4165

Transcripts

ID Sequence Length GC content
NM_001410702.1 NCBI
CUCUCCUCCUCGCCGCGAGAUGUGCGCGAUAAACGGCCGGCGCUCGGGA… 3198 nt 0.4190
NM_080657.5 NCBI
GCUCUGCUCCAGGCAUCUGCCACAAUGUGGGUGCUUACACCUGCUGCUU… 3407 nt 0.4165
Summary

The protein encoded by this gene is an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to viral proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including influenza virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020]

Forensic Context

A study in humans demonstrated that the RSAD2 is a differentially expressed mRNA associated with age prediction, being elevated in middle-aged individuals and linked to type I interferon signaling [Liao et al. DOI:10.1016/J.Fsigen.2025.103373]. In a separate human study on sepsis, the RSAD2 was identified as a downregulated mRNA biomarker in patients compared to healthy controls [Qin et al. DOI:10.1097/JCMA.0000000000000209].