Basic Information

Symbol
RTN4
RNA class
mRNA
Alias
Reticulon 4 NOGO KIAA0886 NSP-CL ASY Neuroendocrine-Specific Protein C Homolog Neurite Outgrowth Inhibitor Reticulon-4 Foocen NOGOA NOGOB RTN-X NSP Neuroendocrine-Specific Protein Neurite Growth Inhibitor 220 My043 Protein Nogo Protein Human NogoA Reticulon 5 Reticulon-5 NI220/250 Nbla00271 Nbla10545 RTN4-B1 RTN4-B2 RTN4-A RTN4-C NOGOC
Location (GRCh38)
2:54972187-55112621
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_020532.5
Sequence length
4697.0 nt
GC content
0.4386

Transcripts

ID Sequence Length GC content
NM_001321859.2 NCBI
GACUCACUCUCUUACCAUGUAAGAGUCCAGCAGGCAAGGCCCCAAACUC… 4546 nt 0.4028
NM_001321860.1 NCBI
AGUCCCUGCCCUCCCCUGGGGAGGGUGAGUCACGCCAAACUGGGCGGAG… 4188 nt 0.3959
NM_001321861.2 NCBI
GUGUGCAGCCCCAGAUGCUUUGGGCUGGUCCCUCCUCUCCGCCCCGAGG… 4124 nt 0.3967
NM_001321862.2 NCBI
AUAACGACGUUUAGGUCAAGGACAGACCGCAUUUGCAACGGUGGCUCCA… 4111 nt 0.3894
NM_001321863.2 NCBI
AGAUAGUCUCCCCCUUGUCACCAGGCUGGAGUGCAAUGACGCAAUCUUG… 4501 nt 0.3961
NM_001321904.2 NCBI
AGGACCACGCUGCACAGGCCUGCGGCAGGUUCCGCUUGCCCAGAGCUUU… 4539 nt 0.4007
NM_007008.3 NCBI
AGUCCUGCUGCAGUUGUGCAGCAGAGGAGACUGCAGACUUCGGUUGAGG… 1719 nt 0.3880
NM_020532.5 NCBI
AUUGUUCCGGGAGCCGUCACCACAGUAGGUCCCUCGGCUCAGUCGGCCC… 4697 nt 0.4386
NM_153828.3 NCBI
AUUGUUCCGGGAGCCGUCACCACAGUAGGUCCCUCGGCUCAGUCGGCCC… 2240 nt 0.4920
NM_207520.2 NCBI
AUUGUUCCGGGAGCCGUCACCACAGUAGGUCCCUCGGCUCAGUCGGCCC… 2297 nt 0.4928
Showing 1 to 10 of 11 entries
Summary

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the RTN4 was differentially expressed between monozygotic twins, belonging to the least variable category of housekeeping genes and classified under signaling and communication [Sharma et al. DOI:10.1152/physiolgenomics.00228.2003]. In a rat model of traumatic brain injury, the RTN4 was upregulated following a severe (50% Lagrangian) stretch injury, where it targets and positively regulates RhoA, implicating it in a specific neurodegenerative pathway [Di Pietro et al. DOI:10.1089/neu.2009.1095].