Basic Information

Symbol
RUNX3
RNA class
mRNA
Alias
RUNX Family Transcription Factor 3 AML2 Runt-Related Transcription Factor 3 PEBP2A3 CBFA3 Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit SL3/AKV Core-Binding Factor Alpha C Subunit SL3-3 Enhancer Factor 1 Alpha C Subunit Runt Related Transcription Factor 3 Core-Binding Factor Subunit Alpha-3 Acute Myeloid Leukemia 2 Protein Oncogene AML-2 CBF-Alpha-3 Core-Binding Factor, Runt Domain, Alpha Subunit 3 Acute Myeloid Leukemia Gene 2 Transcription Factor AML2 PEBP2 Alpha C PEBP2-Alpha C PEA2 Alpha C PEA2-Alpha C PEBP2aC
Location (GRCh38)
1:24899511-24965121
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mixture deconvolution
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004350.3
Sequence length
4267.0 nt
GC content
0.6053

Transcripts

ID Sequence Length GC content
NM_001031680.2 NCBI
AUUCAUUCAUUCCCCGUGGCACUGGAGGCGGCCCACUCUGCUCUGUCAG… 4340 nt 0.5719
NM_001320672.1 NCBI
AUUCAUUCAUUCCCCGUGGCACUGGAGGCGGCCCACUCUGCUCUGUCAG… 4173 nt 0.5794
NM_004350.3 NCBI
GCCACUUGAUUCUGGAGGAUUUGUUCUGGGGCUGCGGCCGCGGAGUCGG… 4267 nt 0.6053
Summary

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Forensic Context

A study in humans demonstrated that the RUNX3 was initially considered a candidate blood-specific marker but failed during the MPS panel construction and was consequently excluded from the final 202-cSNP assay for identifying body fluid origin and donors in mixtures [Liu et al. DOI:10.1016/j.fsigen.2024.103066].