Basic Information

Symbol
RXFP1
RNA class
mRNA
Alias
Relaxin Family Peptide Receptor 1 RXFPR1 LGR7 Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 7 Relaxin/Insulin Like Family Peptide Receptor 1 Relaxin Receptor 1 Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 7
Location (GRCh38)
4:158315311-158653372
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_021634.4
Sequence length
3686.0 nt
GC content
0.3644

Transcripts

ID Sequence Length GC content
NM_001253727.2 NCBI
AGAAAUAGCACACAACCACUGUGAGCUGUAUGCGAUUCAGAAACCAAGA… 3767 nt 0.3661
NM_001253728.2 NCBI
AGAAAUAGCACACAACCACUGUGAGCUGUAUGCGAUUCAGAAACCAAGA… 3587 nt 0.3641
NM_001253729.2 NCBI
AGAAAUAGCACACAACCACUGUGAGCUGUAUGCGAUUCAGAAACCAAGA… 3542 nt 0.3650
NM_001253730.2 NCBI
AGAAAUAGCACACAACCACUGUGAGCUGUAUGCGAUUCAGAAACCAAGA… 3608 nt 0.3656
NM_001253732.2 NCBI
AGAAAUAGCACACAACCACUGUGAGCUGUAUGCGAUUCAGAAACCAAGA… 3770 nt 0.3663
NM_001253733.2 NCBI
AGAAAUAGCACACAACCACUGUGAGCUGUAUGCGAUUCAGAAACCAAGA… 3698 nt 0.3675
NM_001363776.1 NCBI
GUGCGUGUGUGUAAAGAAGGAGAUUAGGACAUUUAGAGAAGGAGGGCGG… 3955 nt 0.3704
NM_021634.4 NCBI
AGAAAUAGCACACAACCACUGUGAGCUGUAUGCGAUUCAGAAACCAAGA… 3686 nt 0.3644
Summary

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Forensic Context

A review of RNA-Seq studies in post-mortem human brains notes that the RXFP1 was identified as a differentially expressed gene in the anterior cingulate cortex of subjects with bipolar disorder, belonging to class A of the G protein-coupled receptor family [Wu et al. DOI:10.1111/Pcn.12550].