Basic Information

Symbol
RXFP2
RNA class
mRNA
Alias
Relaxin Family Peptide Receptor 2 GPR106 GREAT INSL3R RXFPR2 LGR8 Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 8 Relaxin/Insulin Like Family Peptide Receptor 2 G-Protein Coupled Receptor 106 Relaxin Receptor 2 Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 8 G Protein Coupled Receptor Affecting Testicular Descent G-Protein Coupled Receptor Affecting Testicular Descent LGR8.1
Location (GRCh38)
13:31739526-31803389
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_130806.5
Sequence length
3336.0 nt
GC content
0.3939

Transcripts

ID Sequence Length GC content
NM_001166058.2 NCBI
AGAACAUGGGAGGCACUGAACUUACUACAUCAGAACUCCUGCUGAGGUA… 3264 nt 0.3958
NM_130806.5 NCBI
AGAACAUGGGAGGCACUGAACUUACUACAUCAGAACUCCUGCUGAGGUA… 3336 nt 0.3939
Summary

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Forensic Context

A study in humans identified the RXFP2 as a potential diagnostic and severity biomarker for mustard gas chemical injuries, with its expression levels showing significant differences among severity groups (Severe, Moderate, Mild) and healthy controls in PBMC RNA-Seq data [Arabfard et al. DOI:10.1016/j.intimp.2025.114090].