Basic Information

Symbol
RXRA
RNA class
mRNA
Alias
Retinoid X Receptor Alpha NR2B1 Nuclear Receptor Subfamily 2 Group B Member 1 RXR-Alpha RXRalpha Retinoic Acid Receptor RXR-Alpha Retinoid X Nuclear Receptor Alpha Retinoid X Receptor, Alpha
Location (GRCh38)
9:134317098-134440585
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002957.6
Sequence length
5537.0 nt
GC content
0.6099

Transcripts

ID Sequence Length GC content
NM_001291920.2 NCBI
ACAGAUGCCCUGUGCAUGGGGUGGGGAUGAAGGAGGGCUGGGGGCUCCG… 6201 nt 0.6123
NM_001291921.2 NCBI
AGUGCCUCCAAGCGAGACAGCCACUAGACCAGCGAGCCCUGGAGGGCUG… 6014 nt 0.6046
NM_002957.6 NCBI
AGUUUACAUUGUUGGGCGACUUUUGCAACAACUCGCCGCGCCGCGGCCU… 5537 nt 0.6099
Summary

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Forensic Context

A study in mice demonstrated that the transcription factor Rxra was activated in hepatocytes from alcohol-fed mice and was involved in the acute phase response and coagulation during short-term alcoholic liver injury [Cao et al. DOI:10.3390/Ijms24054344].