Basic Information

Symbol
S100A2
RNA class
mRNA
Alias
S100 Calcium Binding Protein A2 CAN19 S100L S100 Calcium-Binding Protein A2 Protein S100-A2 Protein S-100L
Location (GRCh38)
1:153560950-153568674
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005978.4
Sequence length
977.0 nt
GC content
0.5363

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-370.20 kcal/mol
Thermodynamic ensemble
Free energy: -386.78 kcal/mol
Frequency: 0.0000
Diversity: 179.56
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((((......))))).......(((((((.(((((((((.....))).(((((((....(((((..(((((((((.((.(((((((...))))))).)).)))))).)))((((((((((((((.(((((..(((((..((.(((.(((((.(((.((((((((((..((((((....((((....((((((.(((((((((((...((((.(((....(((((((((...............)))))))))....))))).))....)))).))))...))).)))))))))))))))))))))))))).))).))))).)))...))..)))))....))))).)...((((((((.((..((((((((.....)))).(((....)))((((.((....(((((((..((.((((.....))))...))..)).)))))....))..))))...)))).)).)))))))))))))....))))))))..))))).)).)))))((((.....))))..)))))).)))))))((((.(((.(.((((.(((.((...((((((((...(((..((((((((((((((((((((((((.....)))))......(((((.((.......)).)))))..((((((((((((((.(((((((..((....))..)))..))))..))))).......)))))))))..((((((.((.......)).)))))).................))))))).........(((((((...)))))))))))))))))))....))))))))))).....)).))).)))).).)))..)))).((((......))))((((((((((...))))).)))))....(((((....)))))...((((((....(((.....)))......)))))).(((((.(..((((.......))))..).)))))))...
Thermodynamic Ensemble Prediction
...(((((((......))))}....,..(((((((.(((((((((.....))).(((((({..{,(((((..(((((((((.((.(((((((...))))))).)).)))))).)))((((((((((((((.(((((.,(((((..((.(((.(((((.(((.((((((((((..(((({{....((({...{((((((.((((((((((({{{.{{{.((((..,{,((,..}},.,,..}))),,.,|}|(((((.....))))).,,.....)))).))))...))).)))))))))))))))))))))))))).))).))))).)))...))..)))))..,.))))).}...((((((((.((..((((({((..,..)))),|||....,||((({.,...,.(((((((,.{{.((((.....))))...)),.))},)))).....},})),,...)))).)).)))))))))))))}...})))))))..)))))}}).)))))((((.....))))..)))))).)))))))((({.(((.{.((((.(((.((...((((((((...{((.,((((((((((((((((((((((((.....))))}....,.((((({,{.......,).))))),.((((((((((((((.(((((((..((....)}.,))}.,))))..))))).......)))))))))..((((((.((.......)).)))))).,,.......,,,,..,))))))).........(((((((...)))))))))))))))))))..),))))))))))).,,..)).))).)))).}.)))..)))).((((......))))((((((((((...))))).)))))....{(({{....})}},...((((((....(({|...,))),.....)))))).(((((.{..((((.......))))..}.)))))))...

Transcripts

ID Sequence Length GC content
NM_001366406.1 NCBI
CCACAGAUCCAUGAUGUGCAGUUCUCUGGAGCAGGCGCUGGCUGUGCUG… 760 nt 0.4855
NM_001366407.1 NCBI
AGAGCAGGGGUUGCCUCCCCUCACCCCGGUCCAGGAUGCCCAGUCCCCA… 943 nt 0.5366
NM_005978.4 NCBI
AGAGCAGGGGUUGCCUCCCCUCACCCCGGUCCAGGAUGCCCAGUCCCCA… 977 nt 0.5363
Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human skin demonstrated that the S100A2 is significantly up-regulated in thermally injured tissue as part of the inflammatory/immune response during the early wound repair process [Greco et al. DOI:10.1016/j.burns.2009.06.211]. In a separate human study, the S100A2 was identified as a differentially expressed mRNA marker for a distinct kidney proximal tubular cell type in urine samples, contributing to high-accuracy cell and tissue type identification using a single-cell RNA sequencing pipeline developed for forensic applications [Liu et al. DOI:10.1371/journal.pone.0318151].