Basic Information

Symbol
S100A8
RNA class
mRNA
Alias
S100 Calcium Binding Protein A8 MRP8 P8 Migration Inhibitory Factor-Related Protein 8 Leukocyte L1 Complex Light Chain Calprotectin L1L Subunit Cystic Fibrosis Antigen S100-A8 60B8AG MRP-8 CGLA CAGA CFAG Urinary Stone Protein Band A Protein S100-A8 Calgranulin A S100 Calcium-Binding Protein A8 Calgranulin-A CP-10 MA387 L1Ag MIF NIF
Location (GRCh38)
1:153390032-153391142
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002964.5
Sequence length
408.0 nt
GC content
0.4828

Transcripts

ID Sequence Length GC content
NM_001319196.1 NCBI
GAGAAACCAGAGACUGUAGCAACUCUGGCAGGGAGAAGCUGUCUCUGAU… 549 nt 0.4882
NM_001319197.1 NCBI
GAGAAACCAGAGACUGUAGCAACUCUGGCAGGGAGAAGCUGUCUCUGAU… 546 nt 0.4890
NM_001319198.2 NCBI
UGUUUUGAUAUCAGAAUUUCUGGGGAACAUUUGGAUUUCCAGAAUCUCU… 441 nt 0.4649
NM_001319201.2 NCBI
GAGCAGCCUUCCUGAGAGAGGAGAGAGAAAGCUCAGGGAGGUCUGGAGC… 495 nt 0.5051
NM_002964.5 NCBI
AUGUCUCUUGUCAGCUGUCUUUCAGAAGACCUGGUGGGGCAAGUCCGUG… 408 nt 0.4828
Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Forensic Context

A study in humans demonstrated that the S100A8 gene was significantly upregulated in the peripheral blood mononuclear cells of sepsis patients compared to healthy controls, with a log2 fold change of 5.16, and its expression was validated by qRT-PCR, showing a 4.9-fold increase and high diagnostic accuracy with an AUROC >0.8 [Wu et al. DOI:10.7150/ijms.46910]. A separate multi-omics study in humans and mice identified the S100A8 protein as an early warning marker for severe burn-associated sepsis, showing statistically different levels between non-sepsis and sepsis groups on Burn-day 1 with an AUC of 0.69, and in a mouse model of severe burn injury, inhibition of the S100A8 protein with paquinimod increased survival rates, inhibited neutrophil mobilization, and reduced inflammatory cytokine release [Huang et al. DOI:10.1093/burnst/tkac050]. A review of forensic proteomics literature notes that the S100A8 is a protein marker for donor profiling, specifically for sex determination, where it is found to be markedly higher in females within the oral fluid proteome [Alex et al. DOI:10.1016/j.scijus.2025.101320].