Basic Information

Symbol
S1PR5
RNA class
mRNA
Alias
Sphingosine-1-Phosphate Receptor 5 Edg-8 EDG8 Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 8 Endothelial Differentiation G-Protein-Coupled Receptor 8 Sphingosine 1-Phosphate Receptor Edg-8 Sphingosine 1-Phosphate Receptor 5 S1P Receptor Edg-8 S1P Receptor 5 S1P5 Sphingosine 1-Phosphate Receptor EDG8 SPPR-1 SPPR-2
Location (GRCh38)
19:10512742-10517931
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_030760.5
Sequence length
2338.0 nt
GC content
0.5984

Transcripts

ID Sequence Length GC content
NM_001166215.2 NCBI
AGCGGGAACCUAUCUGCUGGUGGGAGAGGACUCAGGCUAAGGUGGCCCC… 2430 nt 0.5967
NM_030760.5 NCBI
ACUCGGUUCAAGGCAGCGCGACUGCGGGUGGCGCACGACCAGGGCGCAG… 2338 nt 0.5984
Summary

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

Forensic Context

A study in mouse cardiac mesenchymal stem cells demonstrated that overexpression of HDAC11 induced transcriptional reprogramming, activating cell cycle pathways and promoting proliferation, as evidenced by increased pHH3 protein levels [Zhang et al. DOI:10.3390/biom15050662].