Basic Information

Symbol
SAA2
RNA class
mRNA
Alias
Serum Amyloid A2 Serum Amyloid A-2 Protein Serum Amyloid A-1 Protein SAA1 SAA
Location (GRCh38)
11:18239223-18248668
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_030754.5
Sequence length
576.0 nt
GC content
0.5382

Transcripts

ID Sequence Length GC content
NM_001127380.3 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 2034 nt 0.3889
NM_001385666.1 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 637 nt 0.5306
NM_001385667.1 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 2095 nt 0.3909
NM_001385668.1 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 437 nt 0.5332
NM_001385669.1 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 384 nt 0.5130
NM_001385670.1 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 483 nt 0.5280
NM_001385671.1 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 481 nt 0.5385
NM_001385672.1 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 2023 nt 0.3900
NM_030754.5 NCBI
ACUAUAAAUAGCAGCCACCUCUCCCUGGCAGACAGGGACCCGCAGCUCA… 576 nt 0.5382
Summary

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. [provided by RefSeq, Jul 2020]

Forensic Context

A study in mice demonstrated that elevated protein levels of the SAA2 in serum on days 5-7 after lethal irradiation were closely related to lethal injury [Jia et al. DOI:10.1016/j.toxlet.2024.07.911]. A study in mice demonstrated that the SAA2 is expressed in the brain following traumatic brain injury, colocalizing with astrocytes and microglia/macrophages in specific brain regions, and exhibits a sex-dependent expression pattern with higher levels in males at early time points post-injury [Soriano et al. DOI:10.1007/s10571-020-00808-3].