Basic Information

Symbol
SAR1A
RNA class
mRNA
Alias
Secretion Associated Ras Related GTPase 1A SAR1 SARA1 Sara Small COPII Coat GTPase SAR1A COPII-Associated Small GTPase Secretion Associated, Ras Related GTPase 1A Secretion-Associated Ras-Related GTPase 1A SAR1a Gene Homolog (S. Cerevisiae) 1 SAR1a Gene Homolog 1 (S. Cerevisiae) SAR1 Homolog A (S. Cerevisiae) GTP-Binding Protein SAR1a SAR1a Gene Homolog 1 SAR1 Gene Homolog A SAR1 Homolog A EC 3.6.5.2 EC 3.6.5 Masra2 SARA
Location (GRCh38)
10:70147289-70170905
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_020150.5
Sequence length
5902.0 nt
GC content
0.4287

Transcripts

ID Sequence Length GC content
NM_001142648.2 NCBI
GUACAUCCGGCGAGUAGCUGGCGGUCCCGGGUGCUGCUGGUUAGUGUGC… 5972 nt 0.4282
NM_020150.5 NCBI
GUACAUCCGGCGAGUAGCUGGCGGUCCCGGGUGCUGCUGGUUAGUGUGC… 5902 nt 0.4287
Summary

Enables G protein activity and amino acid sensor activity. Involved in COPII-coated vesicle budding; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Is active in COPII vesicle coat; endoplasmic reticulum exit site; and lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the SAR1A in oligodendrocytes, as part of broader dysregulation in protein processing of endoplasmic reticulum pathways within cortical glial cells [Oladapo et al. DOI:10.3390/Ijms26020649].