Basic Information

Symbol
SAR1B
RNA class
mRNA
Alias
Secretion Associated Ras Related GTPase 1B SARA2 Small COPII Coat GTPase SAR1B GTP-Binding Protein B GTBPB Secretion Associated, Ras Related GTPase 1B Secretion-Associated Ras-Related GTPase 1B SAR1a Gene Homolog (S. Cerevisiae) 2 SAR1a Gene Homolog 2 (S. Cerevisiae) SAR1 Homolog B (S. Cerevisiae) GTP-Binding Protein SAR1b GTP-Binding Protein Sara SAR1a Gene Homolog 2 SAR1 Homolog B 2310075M17Rik EC 3.6.5.2 EC 3.6.5 ANDD CMRD SARB
Location (GRCh38)
5:134601149-134649271
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016103.4
Sequence length
6517.0 nt
GC content
0.3819

Transcripts

ID Sequence Length GC content
NM_001033503.3 NCBI
GCUGAUGCGAACUGGGGCCACGGCAGCCAUCGCGCUUUGCAGUUCGGUC… 6636 nt 0.3861
NM_016103.4 NCBI
GCUGAUGCGAACUGGGGCCACGGCAGCCAUCGCGCUUUGCAGUUCGGUC… 6517 nt 0.3819
Summary

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the SAR1B in microglia, as part of the protein processing of endoplasmic reticulum pathway, indicating its dysregulation during methamphetamine-induced neurotoxicity [Oladapo et al. DOI:10.3390/Ijms26020649].