Basic Information

Symbol
SAT1
RNA class
mRNA
Alias
Spermidine/Spermine N1-Acetyltransferase 1 SSAT SAT Polyamine N-Acetyltransferase 1 Diamine N-Acetyltransferase 1 Putrescine Acetyltransferase Diamine Acetyltransferase 1 EC 2.3.1.57 SSAT-1 Spermidine/Spermine N1-Acetyltransferase Alpha Spermidine/Spermine N(1)-Acetyltransferase 1 Epididymis Secretory Sperm Binding Protein Spermidine/Spermine N1-Acetyltransferase KFSDX DC21 KFSD
Location (GRCh38)
X:23783173-23786210
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002970.4
Sequence length
1049.0 nt
GC content
0.4385

Transcripts

ID Sequence Length GC content
NM_002970.4 NCBI
GCGCAGCUCUUAGUCGCGGGCCGACUGGUGUUUAUCCGUCACUCGCCGA… 1049 nt 0.4385
Summary

The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

Forensic Context

A study in rats demonstrated that skeletal muscle contusion induces iron overload and ferroptosis, characterized by increased Fe2+ and MDA alongside decreased GSH and GPX4 levels, which were reversed by ferroptosis inhibitors [Yang et al. DOI:10.3390/ijms252011317].