Basic Information

Symbol
SATB1
RNA class
mRNA
Alias
SATB Homeobox 1 Special AT-Rich Sequence Binding Protein 1 (Binds To Nuclear Matrix/Scaffold-Associating DNA) DNA-Binding Protein SATB1 Special AT-Rich Sequence-Binding Protein 1 DEFDA DHDBV KTZSL
Location (GRCh38)
3:18345377-18445621
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002971.6
Sequence length
7822.0 nt
GC content
0.4256

Transcripts

ID Sequence Length GC content
NM_001131010.4 NCBI
GCAGUAAUGGUCCAGCUGCUUCACAGGCAACUGGUAACCACCUCAUUUG… 6281 nt 0.3896
NM_001195470.3 NCBI
ACUUUCUCGCUCGCUCCCGUUCCCCGGACGCGGCGGAUGAGCCGGCCCC… 7918 nt 0.4280
NM_001322871.2 NCBI
CCUUCCCUUGGCCCCGCGCGCUCGCUCGCUCGCUCCUCGCCUCGCUCUC… 6471 nt 0.4032
NM_001322872.2 NCBI
AGCCAAACAACAAGCAACAAGAGGAAGCCGCAGGCGACAAGAGGAGGAG… 6370 nt 0.3992
NM_001322873.2 NCBI
CCUUCCCUUGGCCCCGCGCGCUCGCUCGCUCGCUCCUCGCCUCGCUCUC… 6375 nt 0.3998
NM_001322874.2 NCBI
AGCCAAACAACAAGCAACAAGAGGAAGCCGCAGGCGACAAGAGGAGGAG… 6184 nt 0.3902
NM_001322875.2 NCBI
GCGAGUCUGCUCAGCAUCCUUUCCCGGUCCAUCUCCGCCUCCCUCCGCU… 6178 nt 0.3904
NM_001322876.2 NCBI
CCUUCCCUUGGCCCCGCGCGCUCGCUCGCUCGCUCCUCGCCUCGCUCUC… 6140 nt 0.3963
NM_002971.6 NCBI
ACUUUCUCGCUCGCUCCCGUUCCCCGGACGCGGCGGAUGAGCCGGCCCC… 7822 nt 0.4256
Summary

This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]

Forensic Context

A study in humans undergoing cardiac surgery demonstrated that the SATB1 mRNA was a predicted target of the upregulated miRNA miR-483-3p and showed a strong anticorrelated expression pattern (Pearson r = -0.72) in postischemic left ventricular tissue, suggesting a role in the transcriptional response to acute myocardial ischemia [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015]. Separately, a study in a Chinese human population identified the SATB1 as one of several age-related mRNA markers from peripheral blood, where it was used to construct a machine learning-based age prediction model that achieved a mean absolute error of 6.72 years on a test set [Liao et al. DOI:10.1016/J.Fsigen.2025.103373].