Basic Information

Symbol
SAXO2
RNA class
mRNA
Alias
Stabilizer Of Axonemal Microtubules 2 FAM154B Family With Sequence Similarity 154, Member B DKFZp666G057 Protein FAM154B
Location (GRCh38)
15:82262810-82284930
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_001348699.2
Sequence length
3304.0 nt
GC content
0.3798

Transcripts

ID Sequence Length GC content
NM_001008226.2 NCBI
GACUACGGCGGGCGCUGUGGGAGUGGAGAAGCUGCAAGUGCUGAGGCGC… 3124 nt 0.3796
NM_001348699.2 NCBI
GACUACGGCGGGCGCUGUGGGAGUGGAGAAGCUGCAAGUGCUGAGGCGC… 3304 nt 0.3798
NM_001348700.2 NCBI
GACUACGGCGGGCGCUGUGGGAGUGGAGAAGCUGCAAGUGCUGAGGCGC… 3560 nt 0.3986
NM_001348701.2 NCBI
GACUACGGCGGGCGCUGUGGGAGUGGAGAAGCUGCAAGUGCUGAGGCGC… 3354 nt 0.3825
NM_001348702.2 NCBI
GACUACGGCGGGCGCUGUGGGAGUGGAGAAGCUGCAAGUGCUGAGGCGC… 3532 nt 0.3998
NM_001348703.2 NCBI
GACUACGGCGGGCGCUGUGGGAGUGGAGAAGCUGCAAGUGCUGAGGCGC… 3276 nt 0.3810
NM_001348705.2 NCBI
GACUACGGCGGGCGCUGUGGGAGUGGAGAAGCUGCAAGUGCUGAGGCGC… 462 nt 0.5173
NM_001348706.2 NCBI
GACUACGGCGGGCGCUGUGGGAGUGGAGAAGCUGCAAGUGCUGAGGCGC… 3104 nt 0.3782
Summary

Predicted to enable microtubule binding activity. Predicted to be active in microtubule cytoskeleton; nucleus; and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in human cardiac stromal cells from arrhythmogenic cardiomyopathy (ACM) patients identified SAXO2 as a significantly up-regulated gene in ACM samples compared to healthy controls [Rainer et al. DOI:10.1186/s12864-018-4876-6]. This differential expression was confirmed by RT-qPCR validation in an extended sample set, establishing it as part of the ACM-specific transcriptomic signature.