Basic Information

Symbol
SBK1
RNA class
mRNA
Alias
SH3 Domain Binding Kinase 1 Serine/Threonine-Protein Kinase SBK1 Sbk SH3-Binding Domain Kinase 1 EC 2.7.11.1 SH3 Domain-Binding Kinase 1 EC 2.7.11
Location (GRCh38)
16:28259246-28323849
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001024401.3
Sequence length
4986.0 nt
GC content
0.6448

Transcripts

ID Sequence Length GC content
NM_001024401.3 NCBI
GAUGCCGCGAUGGAGCGCAGCCCGGGCGGGCGCCGGGGCCGGGGCCCGA… 4986 nt 0.6448
Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in mice and zebrafish demonstrated that the SBK1 transcript increased in abundance within 0.5 hours postmortem, with its profile identified among 1063 genes showing significant increases after death [Pozhitkov et al. DOI:10.1098/rsob.160267]. In human sepsis research, the SBK1 mRNA was identified as downregulated in the peripheral blood of septic patients compared to healthy controls [Qin et al. DOI:10.1097/JCMA.0000000000000209].