Basic Information

Symbol
SCARB1
RNA class
mRNA
Alias
Scavenger Receptor Class B Member 1 CLA-1 SR-BI SRB1 CLA1 CD36L1 CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 1 CD36 And LIMPII Analogous 1 Collagen Type I Receptor, Thrombospondin Receptor-Like 1 Scavenger Receptor Class B, Member 1 Scavenger Receptor Class B Type III CD36 Antigen-Like 1 CD36 Antigen HDLQTL6 HDLCQ6
Location (GRCh38)
12:124776856-124882668
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005505.5
Sequence length
3405.0 nt
GC content
0.5604

Transcripts

ID Sequence Length GC content
NM_001082959.2 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3276 nt 0.5647
NM_001367981.1 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3526 nt 0.5723
NM_001367982.1 NCBI
AAAUCGGGGCCCAUGUGUGCCGUUGGGAAUGUAGGAUGGUGCAGCUGCU… 2357 nt 0.5469
NM_001367983.1 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3411 nt 0.5602
NM_001367984.1 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3402 nt 0.5603
NM_001367985.1 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3381 nt 0.5608
NM_001367986.1 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3321 nt 0.5589
NM_001367987.1 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3078 nt 0.5643
NM_001367988.1 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3003 nt 0.5594
NM_001367989.1 NCBI
CCUGCGUGCGCUGCCGUCCCGGAUCCACCGUGCCUCUGCGGCCUGCGUG… 3416 nt 0.5606
Showing 1 to 10 of 11 entries
Summary

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]

Forensic Context

A study in mice demonstrated that Cd36 is a marker for capillary endothelial cells involved in trans-endothelial lipid processing within interscapular brown adipose tissue, as identified through single-nucleus mRNA-sequencing [Behrens et al. DOI:10.1016/j.molmet.2025.102252]. A study in mice demonstrated that the SCARB1 was over-expressed in liver tissue following Kupffer cell-specific and endothelial cell-specific exposures to α-particles, as well as after neutron exposure, as part of a broader inflammatory response characterized by acute-phase protein upregulation [Roudkenar et al. DOI:10.1269/jrr.07078]. In a separate study in rats, the SCARB1 was identified as a metabolism gene involved in lipid catabolism and was significantly down-regulated in liver tissue on day 2 following a 20% total body surface area burn injury [Jayaraman et al. DOI:10.1016/j.jss.2007.05.025].