Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| ACAGGAACUUCAGCACCCACAGGGCGGACAGCGCUCCCCUCUACCUGGA… | 3107 nt | 0.4100 | |
| ACAGGAACUUCAGCACCCACAGGGCGGACAGCGCUCCCCUCUACCUGGA… | 3160 nt | 0.4085 |
Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Forensic Context
A study in humans using post-mortem tissue RNA sequencing demonstrated that the SCG3 gene was downregulated in the kidneys as part of the haemostasis pathway in sepsis patients who succumbed to septic shock [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938].