Basic Information

Symbol
SCG5
RNA class
mRNA
Alias
Secretogranin V SGNE1 7B2 SgV Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein) Secretory Granule Endocrine Protein I Prohormone Convertase Chaperone Neuroendocrine Protein 7B2 Pituitary Polypeptide Secretogranin-5 P7B2
Location (GRCh38)
15:32641385-32697098
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001144757.3
Sequence length
1198.0 nt
GC content
0.4616

Transcripts

ID Sequence Length GC content
NM_001144757.3 NCBI
AGUUCGCCCGUUCCUGGCCUGACCCCCACCAAGGCCCAUACCGCAGUAG… 1198 nt 0.4616
NM_001394278.1 NCBI
AGUUCGCCCGUUCCUGGCCUGACCCCCACCAAGGCCCAUACCGCAGUAG… 1144 nt 0.4607
NM_001394279.1 NCBI
AGUUCGCCCGUUCCUGGCCUGACCCCCACCAAGGCCCAUACCGCAGUAG… 1141 nt 0.4601
NM_003020.5 NCBI
AGUUCGCCCGUUCCUGGCCUGACCCCCACCAAGGCCCAUACCGCAGUAG… 1195 nt 0.4611
Summary

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

Forensic Context

A study in mice demonstrated that the SCG5 mRNA was downregulated in ante-mortem burned skin compared to control tissue [Liu et al. DOI:10.1007/s12024-022-00474-5].