Basic Information

Symbol
SCN4B
RNA class
mRNA
Alias
Sodium Voltage-Gated Channel Beta Subunit 4 LQT10 Sodium Channel, Voltage-Gated, Type IV, Beta Subunit Sodium Channel Regulatory Subunit Beta-4 Sodium Channel, Voltage Gated, Type IV Beta Subunit Sodium Channel, Voltage-Gated, Type IV, Beta Sodium Channel Subunit Beta-4 Navbeta4 ATFB17
Location (GRCh38)
11:118133377-118152888
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_174934.4
Sequence length
4487.0 nt
GC content
0.5505

Transcripts

ID Sequence Length GC content
NM_001142348.2 NCBI
GCUCUCUGCCCGCUAACUUUCCCGAGCCCCGACCGGCGGCGCAGAGCUC… 4085 nt 0.5518
NM_001142349.2 NCBI
AGUCCUUUCCAGGGGAGAAAUGGAGAAUGAUGGAGGGUGGCCCAGGCGG… 4480 nt 0.5444
NM_174934.4 NCBI
GCUCUCUGCCCGCUAACUUUCCCGAGCCCCGACCGGCGGCGCAGAGCUC… 4487 nt 0.5505
Summary

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

Forensic Context

A study in humans demonstrated that the SCN4B was listed among differentially expressed cardiac-related genes in sudden unexplained death (SUD) cases, with mutations reported in ion channelopathies or cardiomyopathies [Neubauer et al. DOI:10.1007/S00414-025-03414-4]. In a mouse model of myocardial infarction, the SCN4B mRNA, a component of the Nav1.4 channel, was decreased in ischemic heart tissue three days after coronary artery ligation and was identified as a predicted target of miR-125a and miR-351 [Williams et al. DOI:10.1152/physiolgenomics.00041.2020].