Basic Information

Symbol
SCRIB
RNA class
mRNA
Alias
Scribble Planar Cell Polarity Protein SCRB1 KIAA0147 Vartul Protein Scribble Homolog OSCRIB CRIB1 SCRIB Overlapping Open Reading Frame Protein Scribbled Planar Cell Polarity Protein Scribbled Homolog (Drosophila) Scribbled Homolog Protein LAP4 Scribble SCRIB1 VARTUL HScrib LAP4
Location (GRCh38)
8:143790920-143815773
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt UniProt GTEx

MANE select

Transcript ID
NM_182706.5
Sequence length
5607.0 nt
GC content
0.6759

Transcripts

ID Sequence Length GC content
NM_015356.5 NCBI
GGACUCGGCUUCCCGACGGGCUGCGCGGCGGCCGGGUGGGUGUCGGCGG… 5532 nt 0.6779
NM_182706.5 NCBI
GGACUCGGCUUCCCGACGGGCUGCGCGGCGGCCGGGUGGGUGUCGGCGG… 5607 nt 0.6759
Summary

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Forensic Context

No relevant information is available at the moment.