Basic Information

Symbol
SCX
RNA class
mRNA
Alias
Scleraxis BHLH Transcription Factor BHLHa48 BHLHa41 SCXA SCXB Scleraxis Basic Helix-Loop-Helix Transcription Factor Basic Helix-Loop-Helix Transcription Factor Scleraxis Class A Basic Helix-Loop-Helix Protein 41 Class A Basic Helix-Loop-Helix Protein 48 Class II BHLH Protein Scleraxis Scleraxis Homolog A (Mouse) Scleraxis Homolog B (Mouse) Scleraxis Homolog (Mouse) Scleraxis Homolog A Scleraxis Homolog B BHLHA41 BHLHA48
Location (GRCh38)
8:144266453-144268481
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001080514.3
Sequence length
1106.0 nt
GC content
0.7116

Transcripts

ID Sequence Length GC content
NM_001080514.3 NCBI
GGCCCGGGACGCACAUGUGCGCGCGACGCCCGGCAGCUGCCACCGCGGG… 1106 nt 0.7116
Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human corpus cavernosum tissue identified the SCX as a gene marker expressed in the FB4 fibroblast subcluster, contributing to a tenogenic signature [Zhao et al. DOI:10.1038/s41467-022-31950-9].