Basic Information

Symbol
SDCBP
RNA class
mRNA
Alias
Syndecan Binding Protein MDA-9 SYCL Syntenin-1 SDCBP1 Pro-TGF-Alpha Cytoplasmic Domain-Interacting Protein 18 Syndecan-Binding Protein 1 Scaffold Protein Pbp1 TACIP18 MDA9 Melanoma Differentiation Associated Protein-9 Melanoma Differentiation-Associated Protein 9 Syndecan Binding Protein (Syntenin) Syntenin ST1
Location (GRCh38)
8:58552924-58583800
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005625.4
Sequence length
2073.0 nt
GC content
0.3821

Transcripts

ID Sequence Length GC content
NM_001007067.2 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGAAUCCU… 2070 nt 0.3821
NM_001007068.2 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGAAGAAU… 2055 nt 0.3825
NM_001007069.2 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGAAGAAU… 2070 nt 0.3816
NM_001007070.2 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGAAUCCU… 2067 nt 0.3817
NM_001330537.2 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGGUGCCC… 3582 nt 0.3911
NM_001348339.2 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGAAGAAU… 1896 nt 0.3829
NM_001348340.2 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGGUGCCC… 3582 nt 0.3914
NM_001348341.2 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGGUGCCC… 3585 nt 0.3914
NM_005625.4 NCBI
AGUGACCGGAGGCGGCGGCGGCGAGCGGUUCCUUGUGGGCUAGAAGAAU… 2073 nt 0.3821
Summary

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]

Forensic Context

A study in humans and mice demonstrated that the SDCBP is upregulated in peripheral blood mononuclear cells of patients who develop heart failure after acute myocardial infarction and is highly expressed in neutrophils and monocytes/macrophages in infarcted mouse hearts [Chen et al. DOI:10.3389/fimmu.2022.878876].