Basic Information

Symbol
SEC13
RNA class
mRNA
Alias
SEC13 Homolog, Nuclear Pore And COPII Component SEC13R SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component D3S1231E SEC13L1 Npp-20 GATOR2 Complex Protein SEC13 Protein SEC13 Homolog SEC13-Related Protein SEC13-Like Protein 1 SEC13 Homolog, Nuclear Pore And COPII Coating Complex Component SEC13 Homolog (S. Cerevisiae) SEC13 (S. Cerevisiae)-Like 1 SEC13-Like 1 (S. Cerevisiae) GATOR Complex Protein SEC13 SEC13A
Location (GRCh38)
3:10293131-10321123
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_183352.3
Sequence length
1359.0 nt
GC content
0.5475

Transcripts

ID Sequence Length GC content
NM_001136026.3 NCBI
GUUCCGAGGCGCCGCCGGGAGCUGCCACGUCCGAGACCUGGAGCAGCCA… 1537 nt 0.5355
NM_001136232.3 NCBI
UGGUACUGAGGAGGCCUAGCAGGGUGAAGGCCACGGUCGCGGCCUUCAC… 1467 nt 0.5521
NM_001278946.2 NCBI
GUUCCGAGGCGCCGCCGGGAGCUGCCACGUCCGAGACCUGGAGCAGCCA… 899 nt 0.5717
NM_030673.4 NCBI
GUUCCGAGGCGCCGCCGGGAGCUGCCACGUCCGAGACCUGGAGCAGCCA… 1393 nt 0.5449
NM_183352.3 NCBI
GUUCCGAGGCGCCGCCGGGAGCUGCCACGUCCGAGACCUGGAGCAGCCA… 1359 nt 0.5475
Summary

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]

Forensic Context

A study in mice demonstrated that the SEC13 was down-regulated in brain tissue at 8 hours (0.495-fold) and 24 hours (0.451-fold) following whole-body irradiation with 10 Gy γ-rays, identifying it as a protein transport/folding marker responsive to ionizing radiation [Zhao et al. DOI:10.1158/1078-0432.CCR-05-2418].