Basic Information

Symbol
SEC14L1
RNA class
mRNA
Alias
SEC14 Like Lipid Binding 1 PRELID4A SEC14L SEC14-Like Protein 1 SEC14 (S. Cerevisiae)-Like 1 SEC14-Like 1 (S. Cerevisiae) SEC14-Like Lipid Binding 1
Location (GRCh38)
17:77088749-77217101
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001143998.2
Sequence length
5500.0 nt
GC content
0.5135

Transcripts

ID Sequence Length GC content
NM_001039573.3 NCBI
CCCGCCUCCCCGGCCCCCUCCCCGGAACCGGCGGUCGAGCUACGGUCGC… 2971 nt 0.4981
NM_001143998.2 NCBI
CCCGCCUCCCCGGCCCCCUCCCCGGAACCGGCGGUCGAGCUACGGUCGC… 5500 nt 0.5135
NM_001143999.2 NCBI
CCCGCCUCCCCGGCCCCCUCCCCGGAACCGGCGGUCGAGCUACGGUCGC… 5496 nt 0.5135
NM_001144001.2 NCBI
AGUGCAUUUGGUGGCAGAGUGACAGGCUUGGAAGAGAAUGUGGAGGGAG… 5334 nt 0.5122
NM_001204408.2 NCBI
AAGUGGAGACACGUGCUUUGGCCUGUUGGAGGGGAAACCCGCUCUCGCC… 3320 nt 0.4994
NM_001204410.2 NCBI
AAGUGGAGACACGUGCUUUGGCCUGUUGGAGGGGAAACCCGCUCUCGCC… 5849 nt 0.5133
NM_003003.4 NCBI
CCCGCCUCCCCGGCCCCCUCCCCGGAACCGGCGGUCGAGCUACGGUCGC… 5447 nt 0.5118
Summary

The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]

Forensic Context

A study in rats demonstrated that the SEC14L1 was significantly upregulated in left ventricular tissues from an ischemic cardiomyopathy model created via coronary artery ligation, confirming its differential expression as one of twelve validated genes from human microarray data mining [Wang et al. DOI:10.1007/s12031-018-1066-6].