Basic Information

Symbol
SEC14L2
RNA class
mRNA
Alias
SEC14 Like Lipid Binding 2 TAP SPF Supernatant Protein Factor KIAA1186 KIAA1658 C22orf6 TAP1 Alpha-Tocopherol-Associated Protein Tocopherol-Associated Protein 1 Squalene Transfer Protein SEC14-Like Protein 2 SEC14 (S. Cerevisiae)-Like 2 SEC14-Like 2 (S. Cerevisiae) SEC14-Like Lipid Binding 2 HTAP
Location (GRCh38)
22:30396941-30425303
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012429.5
Sequence length
4207.0 nt
GC content
0.5524

Transcripts

ID Sequence Length GC content
NM_001204204.3 NCBI
GACUUUACUCCGGGUGGCGGCGAGGACGAGUCUGUGCUCCAUCAGCUGC… 3958 nt 0.5536
NM_001291932.2 NCBI
GACUUUACUCCGGGUGGCGGCGAGGACGAGUCUGUGCUCCAUCAGCUGC… 4131 nt 0.5522
NM_012429.5 NCBI
GACUUUACUCCGGGUGGCGGCGAGGACGAGUCUGUGCUCCAUCAGCUGC… 4207 nt 0.5524
NM_033382.3 NCBI
GACUUUACUCCGGGUGGCGGCGAGGACGAGUCUGUGCUCCAUCAGCUGC… 1752 nt 0.5228
Summary

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Forensic Context

A study in human trauma patients demonstrated that SEC14L2 mRNA was significantly downregulated in circulating CD3+ T cells during the injury stage compared to the recovery stage [Rau et al. DOI:10.2147/JIR.S375881].