Basic Information

Symbol
SEC23A
RNA class
mRNA
Alias
SEC23 Homolog A, COPII Component SEC23 Homolog A, COPII Coat Complex Component Protein Transport Protein Sec23A SEC23-Related Protein A HSec23A Sec23 Homolog A, Coat Complex II Component Sec23 (S. Cerevisiae) Homolog A Sec23 Homolog A (S. Cerevisiae) CLSD
Location (GRCh38)
14:39031918-39109646
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006364.4
Sequence length
3843.0 nt
GC content
0.3950

Transcripts

ID Sequence Length GC content
NM_006364.4 NCBI
GUGGCAGAGGCGGCGCCAGCCAUGUUGGCCGGGCGGAGGUCUUCGCUGA… 3843 nt 0.3950
Summary

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the SEC23A gene in microglia, which is involved in the protein processing of endoplasmic reticulum pathway [Oladapo et al. DOI:10.3390/Ijms26020649].