Basic Information

Symbol
SEC23B
RNA class
mRNA
Alias
SEC23 Homolog B, COPII Component SEC23 Homolog B, COPII Coat Complex Component CDA-II HEMPAS CDAII Protein Transport Protein Sec23B SEC23-Related Protein B HSec23B CDAN2 Congenital Dyserythropoietic Anemia, Type II SEC23 Homolog B, Coat Complex II Component Sec23 (S. Cerevisiae) Homolog B Sec23 Homolog B (S. Cerevisiae) Transport Protein SEC23B SEC23-Like Protein B CWS7
Location (GRCh38)
20:18507520-18561415
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006363.6
Sequence length
3026.0 nt
GC content
0.4428

Transcripts

ID Sequence Length GC content
NM_001172745.3 NCBI
GUUGCAGCUGUGGGUGAGGACGGCUCUAGCUAGGUGAGCGGCUCCGGCC… 3351 nt 0.4578
NM_001172746.3 NCBI
GUUGCAGCUGUGGGUGAGGACGGCUCUAGCUAGGUGAGCGGCUCCGGCC… 2990 nt 0.4431
NM_006363.6 NCBI
GUUGCAGCUGUGGGUGAGGACGGCUCUAGCUAGUUCCCUUUUAGACUAU… 3026 nt 0.4428
NM_032985.6 NCBI
GUUGCAGCUGUGGGUGAGGACGGCUCUAGCUAGGUGAGCGGCUCCGGCC… 3044 nt 0.4448
NM_032986.5 NCBI
AUACGUCAUCGUUCUCGCUUUCCGGUAGCUAAGGCGAUCAGCGGGACUU… 3115 nt 0.4459
Summary

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the SEC23B gene in oligodendrocytes, which is involved in the protein processing of endoplasmic reticulum pathway [Oladapo et al. DOI:10.3390/Ijms26020649].