Basic Information

Symbol
SEC24A
RNA class
mRNA
Alias
SEC24 Homolog A, COPII Component SEC24 Homolog A, COPII Coat Complex Component Protein Transport Protein Sec24A SEC24-Related Protein A SEC24 (S. Cerevisiae) Related Gene Family, Member A SEC24 Family, Member A (S. Cerevisiae) SEC24 Related Gene Family, Member A SEC24 Family, Member A SEC24 Family Member A
Location (GRCh38)
5:134648588-134727909
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_021982.3
Sequence length
6389.0 nt
GC content
0.3888

Transcripts

ID Sequence Length GC content
NM_001252231.2 NCBI
ACUUCCGGCCAGGGCCUCCCUCCUUCUCUCUAGGUUUGGCUGCCGCCUU… 2737 nt 0.4552
NM_021982.3 NCBI
ACUUCCGGCCAGGGCCUCCCUCCUUCUCUCUAGGUUUGGCUGCCGCCUU… 6389 nt 0.3888
Summary

The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the SEC24A in oligodendrocytes, as identified through single-cell RNA sequencing analysis of cortical glial cells [Oladapo et al. DOI:10.3390/Ijms26020649].