Basic Information

Symbol
SEC31A
RNA class
mRNA
Alias
SEC31 Homolog A, COPII Component ABP125 ABP130 SEC31 Homolog A, COPII Coat Complex Component KIAA0905 SEC31L1 Protein Transport Protein Sec31A SEC31-Related Protein A SEC31-Like Protein 1 Web1-Like Protein SEC31 Homolog A, COPII Coating Complex Component Sec31 Homolog A (S. Cerevisiae) SEC31-Like 1 (S. Cerevisiae) Yeast Sec31p Homolog HSPC275 HSPC334 NEDSOSB HPBKS
Location (GRCh38)
4:82818081-82901166
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001077207.4
Sequence length
4298.0 nt
GC content
0.4502

Transcripts

ID Sequence Length GC content
NM_001077206.4 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 3956 nt 0.4408
NM_001077207.4 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4298 nt 0.4502
NM_001077208.4 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4253 nt 0.4486
NM_001191049.2 NCBI
GUGCGUCGGGUGGGCGGGGAAAGAUGUCGCUCCCGGAAGUGUUGGGCGC… 4328 nt 0.4529
NM_001300744.3 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 3839 nt 0.4384
NM_001300745.3 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4136 nt 0.4466
NM_001318119.2 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4250 nt 0.4485
NM_001318120.2 NCBI
GCAUUUGACCGCUCCUCCCUCCGCGUUGGAGGCGGAAUAGUGGGUUUUG… 4637 nt 0.4516
NM_001400154.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4239 nt 0.4579
NM_001400155.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4236 nt 0.4577
Showing 1 to 10 of 57 entries
Summary

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Forensic Context

A study in mice demonstrated that the SEC31A mRNA expression level was significantly higher in the cecal ligation and puncture (CLP) group compared to the Sham group [Yang et al. DOI:10.1038/s41598-025-06463-2].