Basic Information

Symbol
SEC31A
RNA class
mRNA
Alias
SEC31 Homolog A, COPII Component ABP125 ABP130 SEC31 Homolog A, COPII Coat Complex Component KIAA0905 SEC31L1 Protein Transport Protein Sec31A SEC31-Related Protein A SEC31-Like Protein 1 Web1-Like Protein SEC31 Homolog A, COPII Coating Complex Component Sec31 Homolog A (S. Cerevisiae) SEC31-Like 1 (S. Cerevisiae) Yeast Sec31p Homolog HSPC275 HSPC334 NEDSOSB HPBKS
Location (GRCh38)
4:82818081-82901166
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001077207.4
Sequence length
4298.0 nt
GC content
0.4502

Transcripts

ID Sequence Length GC content
NM_001400156.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4194 nt 0.4564
NM_001400157.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4182 nt 0.4560
NM_001400158.1 NCBI
GUCCUCUUCGCCGGUCCUUAAGCUUUGAGGUAGAGCCCAGGCCAAAACU… 4434 nt 0.4655
NM_001400159.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4185 nt 0.4562
NM_001400160.1 NCBI
GUCCUCUUCGCCGGUCCUUAAGCUUUGAGGUAGAGCCCAGGCCAAAACU… 4410 nt 0.4655
NM_001400161.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4161 nt 0.4561
NM_001400162.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4155 nt 0.4563
NM_001400164.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4143 nt 0.4559
NM_001400165.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4146 nt 0.4561
NM_001400166.1 NCBI
GUCCUCUUCGCCGGUCCUUAAGCUUUGAGGUAGAGCCCAGGCCAAAACU… 4395 nt 0.4655
Showing 11 to 20 of 57 entries
Summary

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Forensic Context

A study in mice demonstrated that the SEC31A mRNA expression level was significantly higher in the cecal ligation and puncture (CLP) group compared to the Sham group [Yang et al. DOI:10.1038/s41598-025-06463-2].