Basic Information

Symbol
SEC31A
RNA class
mRNA
Alias
SEC31 Homolog A, COPII Component ABP125 ABP130 SEC31 Homolog A, COPII Coat Complex Component KIAA0905 SEC31L1 Protein Transport Protein Sec31A SEC31-Related Protein A SEC31-Like Protein 1 Web1-Like Protein SEC31 Homolog A, COPII Coating Complex Component Sec31 Homolog A (S. Cerevisiae) SEC31-Like 1 (S. Cerevisiae) Yeast Sec31p Homolog HSPC275 HSPC334 NEDSOSB HPBKS
Location (GRCh38)
4:82818081-82901166
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001077207.4
Sequence length
4298.0 nt
GC content
0.4502

Transcripts

ID Sequence Length GC content
NM_001400167.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4122 nt 0.4561
NM_001400168.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4119 nt 0.4559
NM_001400180.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4104 nt 0.4542
NM_001400184.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4104 nt 0.4559
NM_001400186.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4107 nt 0.4561
NM_001400188.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4107 nt 0.4543
NM_001400190.1 NCBI
GUCCUCUUCGCCGGUCCUUAAGCUUUGAGGUAGAGCCCAGGCCAAAACU… 4406 nt 0.4646
NM_001400191.1 NCBI
GUCCUCUUCGCCGGUCCUUAAGCUUUGAGGUAGAGCCCAGGCCAAAACU… 4350 nt 0.4641
NM_001400193.1 NCBI
GUCCUCUUCGCCGGUCCUUAAGCUUUGAGGUAGAGCCCAGGCCAAAACU… 4365 nt 0.4653
NM_001400194.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4074 nt 0.4568
Showing 21 to 30 of 57 entries
Summary

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Forensic Context

A study in mice demonstrated that the SEC31A mRNA expression level was significantly higher in the cecal ligation and puncture (CLP) group compared to the Sham group [Yang et al. DOI:10.1038/s41598-025-06463-2].