Basic Information

Symbol
SEC31A
RNA class
mRNA
Alias
SEC31 Homolog A, COPII Component ABP125 ABP130 SEC31 Homolog A, COPII Coat Complex Component KIAA0905 SEC31L1 Protein Transport Protein Sec31A SEC31-Related Protein A SEC31-Like Protein 1 Web1-Like Protein SEC31 Homolog A, COPII Coating Complex Component Sec31 Homolog A (S. Cerevisiae) SEC31-Like 1 (S. Cerevisiae) Yeast Sec31p Homolog HSPC275 HSPC334 NEDSOSB HPBKS
Location (GRCh38)
4:82818081-82901166
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001077207.4
Sequence length
4298.0 nt
GC content
0.4502

Transcripts

ID Sequence Length GC content
NM_001400197.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4065 nt 0.4541
NM_001400198.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4068 nt 0.4543
NM_001400200.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4068 nt 0.4543
NM_001400202.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4065 nt 0.4541
NM_001400203.1 NCBI
GUCCUCUUCGCCGGUCCUUAAGCUUUGAGGUAGAGCCCAGGCCAAAACU… 4317 nt 0.4640
NM_001400204.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4062 nt 0.4545
NM_001400205.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4059 nt 0.4543
NM_001400206.1 NCBI
GUCCUCUUCGCCGGUCCUUAAGCUUUGAGGUAGAGCCCAGGCCAAAACU… 4311 nt 0.4642
NM_001400207.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4026 nt 0.4540
NM_001400208.1 NCBI
GAAUGCUGGGAGAGUCCGACGAGCGCUGCACUAACGCAGGAUCCGGCUG… 4026 nt 0.4550
Showing 31 to 40 of 57 entries
Summary

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Forensic Context

A study in mice demonstrated that the SEC31A mRNA expression level was significantly higher in the cecal ligation and puncture (CLP) group compared to the Sham group [Yang et al. DOI:10.1038/s41598-025-06463-2].