Basic Information

Symbol
SEC61A1
RNA class
mRNA
Alias
SEC61 Translocon Subunit Alpha 1 Protein Transport Protein Sec61 Subunit Alpha Isoform 1 Sec61 Alpha-1 SEC61A Protein Transport Protein SEC61 Alpha Subunit Protein Transport Protein Sec61 Subunit Alpha Sec61 Alpha 1 Subunit (S. Cerevisiae) SEC61 Translocon Alpha 1 Subunit Sec61 Alpha 1 Subunit Sec61 Homolog ADTKD5 CVID15 HSEC61 HNFJ4 SEC61
Location (GRCh38)
3:128051641-128071705
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_013336.4
Sequence length
3568.0 nt
GC content
0.5322

Transcripts

ID Sequence Length GC content
NM_001400328.1 NCBI
AAUCACACCGCCAUGCUUUGCCCACAACAGUCUCCUCAACCUGUUCCCU… 3715 nt 0.5279
NM_001400329.1 NCBI
GACGUGUCUCUCGGCGGAGCUGCUGUGCAGUGGAACGCGCUGGGCCGCG… 3500 nt 0.5334
NM_013336.4 NCBI
GACGUGUCUCUCGGCGGAGCUGCUGUGCAGUGGAACGCGCUGGGCCGCG… 3568 nt 0.5322
Summary

The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the SEC61A1 gene, which is involved in the protein processing of endoplasmic reticulum pathway, within microglial cells as revealed by single-cell RNA sequencing analysis [Oladapo et al. DOI:10.3390/Ijms26020649].