Basic Information

Symbol
SEC61G
RNA class
mRNA
Alias
SEC61 Translocon Subunit Gamma SSS1 Protein Transport Protein Sec61 Subunit Gamma Sec61 Gamma Subunit Protein Transport Protein SEC61 Gamma Subunit SEC61 Translocon Gamma Subunit
Location (GRCh38)
7:54752180-54759974
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014302.4
Sequence length
425.0 nt
GC content
0.3788

Transcripts

ID Sequence Length GC content
NM_001012456.2 NCBI
AUCAGCAAGCUCCAGUGCUACGUGUCCCUGGCAUUUUAGGUGUCGGUUG… 421 nt 0.3777
NM_014302.4 NCBI
AUCAGCAAGCUCCAGUGCUACGUGUCCCUGGCAUUUUAGGUGUCGGUUG… 425 nt 0.3788
Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the SEC61G in both microglia and oligodendrocytes, as identified through single-cell RNA sequencing analysis of cortical glial cells [Oladapo et al. DOI:10.3390/Ijms26020649].